TRANSGENIC MICE AND SQUAMOUS MULTISTAGE SKIN CARCINOGENESIS

被引:41
作者
BROWN, K [1 ]
BALMAIN, A [1 ]
机构
[1] BEATSON INST CANC RES, GLASGOW G61 1BD, LANARK, SCOTLAND
关键词
KERATINOCYTE; INITIATION; PROGRESSION; MALIGNANT CONVERSION; PAPILLOMA; CARCINOMA;
D O I
10.1007/BF00665795
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The use of animals models of human cancers has proved useful in the elucidation of molecular events which occur during tumour development. Mouse skin has been used as a model for human squamous cancer for a number of decades, and analysis of this model has identified a number of changes important for the evolution of malignancy. Transgenic mice offer a further avenue of advancement, allowing refinement of the model, and the ability to examine the consequences of individual events in vivo in greater detail. This article reviews the impact of transgenic approaches to our understanding of multistage squamous carcinogenesis in mouse skin.
引用
收藏
页码:113 / 124
页数:12
相关论文
共 113 条
[21]  
Balmain A., Raden M., Bowden G.T., Smith J., Activation of the mouse cellular Harvey- ras gene in chemically induced benign skin papillomas, Nature, 307, pp. 658-660, (1984)
[22]  
Balmain A., Pragnell I.B., Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey- ras oncogene, Nature, 303, pp. 72-74, (1983)
[23]  
Brown K., Buchmann A., Balmain A., Carcinogen-induced mutations in the mouse c-Ha- ras gene provide evidence of multiple pathways for tumour progression, Proc Natl Acad Sci USA, 87, pp. 538-542, (1990)
[24]  
Nelson M.A., Futscher B.W., Kinsella T., Wymer J., Bowden G.T., Detection of mutant Ha- ras genes in chemically initiated mouse skin epidermis before the development of benign tumours, Proc Natl Acad Sci USA, 89, pp. 6398-6402, (1992)
[25]  
Iannaccone P.M., Weinberg W.C., Deamant F.D., On the clonal origin of tumors: a review of experimental models, Int J Cancer, 39, pp. 778-784, (1987)
[26]  
Winton D.J., Blount M.A., Ponder B.A.J., Polyclonal origin of mouse skin papillomas, Br J Cancer, 60, pp. 59-63, (1989)
[27]  
Nishizuka Y., Studies and perspectives of protein kinase C, Science, 233, pp. 305-312, (1986)
[28]  
Yuspa S.H., Ben T., Hennings H., Lichti U., Divergent responses in epidermal basal cells exposed to the tumour promoter 12-O-decanoylphorbol-13-acetate, Cancer Res, 42, pp. 2344-2349, (1982)
[29]  
Dlugosz A.A., Yuspa S.H., Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C, J Cell Biol, 120, pp. 217-225, (1993)
[30]  
Aldaz C.M., Trono D., Larcher F., Slaga T.J., Conti C.J., Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions, Mol Carcinog, 2, pp. 22-26, (1989)