TRANSGENIC MICE AND SQUAMOUS MULTISTAGE SKIN CARCINOGENESIS

被引：41

作者：

BROWN, K ^{[1
]}

BALMAIN, A ^{[1
]}

机构：

[1] BEATSON INST CANC RES, GLASGOW G61 1BD, LANARK, SCOTLAND

来源：

CANCER AND METASTASIS REVIEWS | 1995年 / 14卷 / 02期

关键词：

KERATINOCYTE; INITIATION; PROGRESSION; MALIGNANT CONVERSION; PAPILLOMA; CARCINOMA;

D O I：

10.1007/BF00665795

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of animals models of human cancers has proved useful in the elucidation of molecular events which occur during tumour development. Mouse skin has been used as a model for human squamous cancer for a number of decades, and analysis of this model has identified a number of changes important for the evolution of malignancy. Transgenic mice offer a further avenue of advancement, allowing refinement of the model, and the ability to examine the consequences of individual events in vivo in greater detail. This article reviews the impact of transgenic approaches to our understanding of multistage squamous carcinogenesis in mouse skin.

引用

页码：113 / 124

页数：12

共 113 条

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