2 GENES ENCODE DISTINCT GLUTAMATE DECARBOXYLASES

被引：1066

作者：

ERLANDER, MG

TILLAKARATNE, NJK

FELDBLUM, S

PATEL, N

TOBIN, AJ

机构：

[1] UNIV CALIF LOS ANGELES,NEUROSCI PROGRAM,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT BIOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

来源：

NEURON | 1991年 / 7卷 / 01期

关键词：

D O I：

10.1016/0896-6273(91)90077-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma-aminobutyric acid (GABA) is the most widely distributed known inhibitory neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in several other organs, including the pancreas. The brain contains two forms of the GABA synthetic enzyme glutamate decarboxylase (GAD), which differ in molecular size, amino acid sequence, antigenicity, cellular and subcellular location, and interaction with the GAD cofactor pyridoxal phosphate. These forms, GAD65 and GAD67, derive from two genes. The distinctive properties of the two GADs provide a substrate for understanding not only the multiple roles of GABA in the nervous system, but also the autoimmune response to GAD in insulin-dependent diabetes mellitus.

引用

页码：91 / 100

页数：10

共 64 条

[11]

CHANG YC, 1988, J NEUROSCI, V8, P2123

[12] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].