MOLECULAR MIMICRY BETWEEN GQ(1B) GANGLIOSIDE AND LIPOPOLYSACCHARIDES OF CAMPYLOBACTER-JEJUNI ISOLATED FROM PATIENTS WITH FISHERS SYNDROME

被引：153

作者：

YUKI, N

TAKI, T

TAKAHASHI, M

SAITO, K

YOSHINO, H

TAI, T

HANDA, S

MIYATAKE, T

机构：

[1] TOKYO MED & DENT UNIV,FAC MED,DEPT NEUROL,BUNKYO KU,TOKYO 113,JAPAN

[2] TOKYO METROPOLITAN RES LAB PUBL HLTH,DEPT MICROBIOL,TOKYO,JAPAN

[3] TOKYO METROPOLITAN INST MED SCI,DEPT TUMOR IMMUNOL,TOKYO 113,JAPAN

来源：

ANNALS OF NEUROLOGY | 1994年 / 36卷 / 05期

关键词：

D O I：

10.1002/ana.410360517

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We isolated Campylobacter jejuni from 2 patients with Fisher's syndrome subsequent to enteritis. Crude lipopolysaccharide fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ(1b) ganglioside (GMR13 and 7F5) reacted with both lipopolysaccharide fractions, indicating that the lipopolysaccharides bear the GQ(1b) epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.

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页码：791 / 793

页数：3

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