PLATELET AGGREGATION .2. ADENYL CYCLASE, PROSTAGLANDIN E1, AND CALCIUM

被引：85

作者：

VIGDAHL, RL

MARQUIS, NR

TAVORMINA, PA

机构：

[1] Department of Biochemistry Mead Johnson Research Center, Evansville, IN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 03期

关键词：

D O I：

10.1016/0006-291X(69)90930-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intracellular cyclic AMP synthesis from ATP generated by incubation of intact human platelets with adenosine-14C is increased by Prostaglandin El (PGEl). The level of cyclic AMP synthesized is temporally related to the degree of inhibition of platelet aggregation effected by PGE1. Aggregation is dependent upon the presence of calcium ions, which inhibit both the stimulation of adenyl cyclase and the inhibition of aggregation by PGE1. © 1969.

引用

页码：409 / +

页数：1