POTENTIAL OF POLYMER MICROENCAPSULATION TECHNOLOGY FOR VACCINE INNOVATION

被引:119
作者
MORRIS, W [1 ]
STEINHOFF, MC [1 ]
RUSSELL, PK [1 ]
机构
[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT INT HLTH, BALTIMORE, MD 21205 USA
关键词
MICROSPHERES; BIODEGRADABLE; CONTROLLED RELEASE;
D O I
10.1016/0264-410X(94)90003-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Biodegradable polymer microspheres or microcapsules developed over the past decade for reliable, preprogrammed release of contraceptive steroids have significant potential for adaptation to antigen release for immunization. In addition,polymeric encapsulation of antigens could prevent the acid and enzymatic degradation that has been a barrier to the development of oral vaccines. This review summarizes the published experience with microencapsulated hormones and antigens, describes the process of microsphere production, discusses the strengths and weaknesses of this approach to immunization, and outlines the gaps in knowledge. Microsphere technology has the potential benefits of reducing the number of inoculations, enhancing the immune response via both parenteral and oral vaccination routes, and in reducing the total antigen dose required to achieve immune protection.
引用
收藏
页码:5 / 11
页数:7
相关论文
共 62 条
[41]   PILI IN MICROSPHERES PROTECT RABBITS FROM DIARRHEA INDUCED BY ESCHERICHIA-COLI STRAIN RDEC-1 [J].
MCQUEEN, CE ;
BOEDEKER, EC ;
REID, R ;
JARBOE, D ;
WOLF, M ;
LE, M ;
BROWN, WR .
VACCINE, 1993, 11 (02) :201-206
[42]   DEGRADATION RATES OF ORAL RESORBABLE IMPLANTS (POLYLACTATES AND POLYGLYCOLATES) - RATE MODIFICATION WITH CHANGES IN PLA-PGA COPOLYMER RATIOS [J].
MILLER, RA ;
BRADY, JM ;
CUTRIGHT, DE .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1977, 11 (05) :711-719
[43]   ORAL IMMUNIZATION WITH INFLUENZA-VIRUS IN BIODEGRADABLE MICROSPHERES [J].
MOLDOVEANU, Z ;
NOVAK, M ;
HUANG, WQ ;
GILLEY, RM ;
STAAS, JK ;
SCHAFER, D ;
COMPANS, RW ;
MESTECKY, J .
JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (01) :84-90
[44]  
MOLDOVEANU Z, 1989, CURR TOP MICROBIOL, V146, P91
[45]  
NUWAYSER ES, 1984, LONG ACTING CONTRACE, P64
[46]   POLY(BUTYL-2-CYANOACRYLATE) PARTICLES AS ADJUVANTS FOR ORAL IMMUNIZATION [J].
OHAGAN, DT ;
PALIN, KJ ;
DAVIS, SS .
VACCINE, 1989, 7 (03) :213-216
[47]   BIODEGRADABLE MICROPARTICLES FOR ORAL IMMUNIZATION [J].
OHAGAN, DT ;
MCGEE, JP ;
HOLMGREN, J ;
MOWAT, AMCL ;
DONACHIE, AM ;
MILLS, KHG ;
GAISFORD, W ;
RAHMAN, D ;
CHALLACOMBE, SJ .
VACCINE, 1993, 11 (02) :149-154
[48]   MICROPARTICLES AS POTENTIALLY ORALLY ACTIVE IMMUNOLOGICAL ADJUVANTS [J].
OHAGAN, DT ;
PALIN, K ;
DAVIS, SS ;
ARTURSSON, P ;
SJOHOLM, I .
VACCINE, 1989, 7 (05) :421-424
[49]  
PITT CG, 1987, CONTRACEPTIVE THER 2, P557
[50]   SINGLE-STEP IMMUNIZATION BY SUSTAINED ANTIGEN RELEASE [J].
PREIS, I ;
LANGER, RS .
JOURNAL OF IMMUNOLOGICAL METHODS, 1979, 28 (1-2) :193-197