COMPLEXATION OF EPHEDRINE WITH BETA-CYCLODEXTRIN - AN NMR-SPECTROSCOPY STUDY

被引:21
作者
NDOU, T [1 ]
MUKUNDAN, S [1 ]
WARNER, IM [1 ]
机构
[1] EMORY UNIV, DEPT CHEM, ATLANTA, GA 30322 USA
来源
JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1993年 / 15卷 / 01期
关键词
BETA-CYCLODEXTRIN; EPHEDRINE; NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM;
D O I
10.1007/BF00706470
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This study focuses on the inclusion complex of ephedrine with beta-CD. The association of beta-CD and ephedrine has been examined using H-1 NMR and circular dichroism. The systematic shifts of the proton resonances of the phenyl moiety of ephedrine and that of the protons located inside the beta-CD cavity, provide evidence of intracavity inclusion. Two-dimensional ROESY show preferential localization of ephedrine in close proximity with protons located inside the beta-CD cavity. The systematic variation of circular dichroism spectra with increasing concentration of beta-CD is used to estimate the apparent formation constant.
引用
收藏
页码:9 / 25
页数:17
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