COMPLEXATION OF EPHEDRINE WITH BETA-CYCLODEXTRIN - AN NMR-SPECTROSCOPY STUDY

被引：21

作者：

NDOU, T ^{[1
]}

MUKUNDAN, S ^{[1
]}

WARNER, IM ^{[1
]}

机构：

[1] EMORY UNIV, DEPT CHEM, ATLANTA, GA 30322 USA

来源：

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1993年 / 15卷 / 01期

关键词：

BETA-CYCLODEXTRIN; EPHEDRINE; NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM;

D O I：

10.1007/BF00706470

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study focuses on the inclusion complex of ephedrine with beta-CD. The association of beta-CD and ephedrine has been examined using H-1 NMR and circular dichroism. The systematic shifts of the proton resonances of the phenyl moiety of ephedrine and that of the protons located inside the beta-CD cavity, provide evidence of intracavity inclusion. Two-dimensional ROESY show preferential localization of ephedrine in close proximity with protons located inside the beta-CD cavity. The systematic variation of circular dichroism spectra with increasing concentration of beta-CD is used to estimate the apparent formation constant.

引用

页码：9 / 25

页数：17

共 56 条

[51] HOMONUCLEAR TWO-DIMENSIONAL H-1-NMR OF PROTEINS - EXPERIMENTAL PROCEDURES [J].