ANTIBODIES TO HISTONE (H2A-H2B) DNA COMPLEXES IN THE ABSENCE OF ANTIBODIES TO DOUBLE-STRANDED DNA OR TO (H2A-H2B) COMPLEXES ARE MORE SENSITIVE AND SPECIFIC FOR SCLERODERMA-RELATED DISORDERS THAN FOR LUPUS

被引：46

作者：

WALLACE, DJ

LIN, HC

SHEN, GQ

PETER, JB

机构：

[1] UNIV CALIF LOS ANGELES,CEDARS SINAI MED CTR,SCH MED,LOS ANGELES,CA 90048

[2] SPECIALTY LABS INC,SANTA MONICA,CA

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 12期

关键词：

D O I：

10.1002/art.1780371213

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To assess the role of antibodies to histones H2A, H2B, and anti-double-stranded DNA which form (H2A-H2B)-DNA complexes in patients with scleroderma-related disorders. Methods. Antihistone antibodies were measured, by enzyme immunoassay, in 26 patients with scleroderma-related disorders, 100 patients with systemic lupus erythematosus (SLE), and 24 patients with rheumatoid arthritis. Results. Antibodies to histone (H2A-H2B)-DNA complex were more commonly seen in patients with scleroderma-related disorders than in those with SLE (P < 0.0001). Conclusion. Scleroderma-related disorders should be included among conditions in which various types of antihistone antibodies are produced. A hypothesis to account for this finding is discussed.

引用

页码：1795 / 1797

页数：3

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