TRICHINELLA-SPIRALIS - CORRELATES INVITRO OF ALTERED IMMUNE RESPONSIVENESS IN MICE

Mixed lymphocyte reactions and in vitro antibody responses to dinitrophenol (DNP) after immunization with DNP-Ficoll were measured in spleen cells from mice following infection with 200 Trichinella spiralis larvae. A depression of the mixed lymphocyte reaction was observed at 14 through 84 days after infection. A reduced response to concanavalin A stimulation was demonstrated over a similar time period, 7 through 63 days of infection. The addition of mitomycin C-treated spleen cells from mice infected with T. spiralis to cultures of normal splenocytes suppressed the mixed lymphocyte reaction by 28% to 65%. The antibody response to DNP-Ficoll immunization was enhanced 20 days after infection, a time when the T-dependent antibody response to sheep erythrocytes was depressed. © 1979.