TRICHINELLA-SPIRALIS - CORRELATES INVITRO OF ALTERED IMMUNE RESPONSIVENESS IN MICE

被引：10

作者：

HALL, BT ^{[1
]}

JONES, JF ^{[1
]}

CRANDALL, RB ^{[1
]}

CRANDALL, CA ^{[1
]}

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT PATHOL,GAINESVILLE,FL 32610

来源：

EXPERIMENTAL PARASITOLOGY | 1979年 / 47卷 / 03期

关键词：

Antibody response; Concanavalin A; DNP-Ficoll; Immunodepression; in vitro; Lymphocyte reaction; Mitomycin C; mixed; Mouse; Nematode; parasitic; Spleen cells; T-independent; Trichinella spiralis;

D O I：

10.1016/0014-4894(79)90083-3

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Mixed lymphocyte reactions and in vitro antibody responses to dinitrophenol (DNP) after immunization with DNP-Ficoll were measured in spleen cells from mice following infection with 200 Trichinella spiralis larvae. A depression of the mixed lymphocyte reaction was observed at 14 through 84 days after infection. A reduced response to concanavalin A stimulation was demonstrated over a similar time period, 7 through 63 days of infection. The addition of mitomycin C-treated spleen cells from mice infected with T. spiralis to cultures of normal splenocytes suppressed the mixed lymphocyte reaction by 28% to 65%. The antibody response to DNP-Ficoll immunization was enhanced 20 days after infection, a time when the T-dependent antibody response to sheep erythrocytes was depressed. © 1979.

引用

页码：305 / 312

页数：8