RIBOSYLATION BY MYCOBACTERIAL STRAINS AS A NEW MECHANISM OF RIFAMPIN INACTIVATION

被引：72

作者：

DABBS, ER

YAZAWA, K

MIKAMI, Y

MIYAJI, M

MORISAKI, N

IWASAKI, S

FURIHATA, K

机构：

[1] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,DIV EXPTL CHEMOTHERAPY,CHUO KU,CHIBA 260,JAPAN

[2] UNIV TOKYO,INST MOLEC & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

[3] UNIV TOKYO,FAC AGR,BUNKYO KU,TOKYO 113,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 04期

关键词：

D O I：

10.1128/AAC.39.4.1007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23- [O-(alpha-D-ribofuranosyl)] rifamycin SV and 23- [O-(alpha-D-ribofuranosyl)] rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation.

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页码：1007 / 1009

页数：3

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