POSSIBLE ROLE OF NATURAL-SELECTION IN THE FORMATION OF TANDEM-REPETITIVE NONCODING DNA

被引:121
作者
STEPHAN, W [1 ]
CHO, S [1 ]
机构
[1] UNIV MARYLAND, DEPT ENTOMOL, College Pk, MD 20742 USA
关键词
D O I
10.1093/genetics/136.1.333
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A simulation model of sequence-dependent amplification, unequal crossing over and mutation is analyzed. This model predicts the spontaneous formation of tandem-repetitive patterns of noncoding DNA from arbitrary sequences for a wide range of parameter values. Natural selection is found to play an essential role in this self-organizing process. Natural selection which is modeled as a mechanism for controlling the length of a nucleotide string but not the sequence itself favors the formation of tandem-repetitive structures. Two measures of sequence heterogeneity, inter-repeat variability and repeat length, are analyzed in detail. For fixed mutation rate, both inter-repeat variability and repeat length are found to increase with decreasing rates of (unequal) crossing over. The results are compared with data on micro-, mini- and satellite DNAs. The properties of minisatellites and satellite DNAs resemble the simulated structures very closely. This suggests that unequal crossing over is a dominant long-range ordering force which keeps these arrays homogeneous even in regions of very low recombination rates, such as at satellite DNA loci. Our analysis also indicates that in regions of low rates of (unequal) crossing over, inter-repeat variability is maintained at a low level at the expense of much larger repeat units (multimeric repeats), which are characteristic of satellite DNA. In contrast, the microsatellite data do not fit the proposed model well, suggesting that unequal crossing over does not act on these very short tandem arrays.
引用
收藏
页码:333 / 341
页数:9
相关论文
共 30 条
[1]   SEQUENCES FLANKING THE REPEAT ARRAYS OF HUMAN MINISATELLITES - ASSOCIATION WITH TANDEM AND DISPERSED REPEAT ELEMENTS [J].
ARMOUR, JAL ;
WONG, Z ;
WILSON, V ;
ROYLE, NJ ;
JEFFREYS, AJ .
NUCLEIC ACIDS RESEARCH, 1989, 17 (13) :4925-4935
[2]  
BACHMANN L, 1993, MOL BIOL EVOL, V10, P647
[3]   THE EVOLUTION OF RESTRICTED RECOMBINATION AND THE ACCUMULATION OF REPEATED DNA-SEQUENCES [J].
CHARLESWORTH, B ;
LANGLEY, CH ;
STEPHAN, W .
GENETICS, 1986, 112 (04) :947-962
[4]   A VNTR IMMEDIATELY ADJACENT TO THE HUMAN PSEUDOAUTOSOMAL TELOMERE [J].
INGLEHEARN, CF ;
COOKE, HJ .
NUCLEIC ACIDS RESEARCH, 1990, 18 (03) :471-476
[5]   MINISATELLITE REPEAT CODING AS A DIGITAL APPROACH TO DNA TYPING [J].
JEFFREYS, AJ ;
MACLEOD, A ;
TAMAKI, K ;
NEIL, DL ;
MONCKTON, DG .
NATURE, 1991, 354 (6350) :204-209
[6]   SPONTANEOUS MUTATION-RATES TO NEW LENGTH ALLELES AT TANDEM-REPETITIVE HYPERVARIABLE LOCI IN HUMAN DNA [J].
JEFFREYS, AJ ;
ROYLE, NJ ;
WILSON, V ;
WONG, Z .
NATURE, 1988, 332 (6161) :278-281
[7]  
Kauffman Stuart A., 1993
[8]   HIGHER RATE OF EVOLUTION OF X-CHROMOSOME ALPHA-REPEAT DNA IN HUMAN THAN IN THE GREAT APES [J].
LAURSEN, HB ;
JORGENSEN, AL ;
JONES, C ;
BAK, AL .
EMBO JOURNAL, 1992, 11 (07) :2367-2372
[9]  
LEVINSON G, 1987, MOL BIOL EVOL, V4, P203
[10]   GENETIC-ANALYSIS OF MEIOSIS IN FEMALE DROSOPHILA-MELANOGASTER [J].
LINDSLEY, DL ;
SANDLER, L .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1977, 277 (955) :295-312