Evaluation of the use of cyclodextrins in chiral separation of basic drug substances by capillary electrophoresis

被引：20

作者：

Bjornsdottir, I

Hansen, SH

机构：

[1] Department of Analytical and Pharmaceutical Chemistry, Royal Danish School of Pharmacy, Copenhagen

来源：

CHIRALITY | 1995年 / 7卷 / 04期

关键词：

chiral separation; cyclodextrins; basic drugs;

D O I：

10.1002/chir.530070407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The influence of the choice of type and/or concentration of cyclodextrin, other additives, the temperature surrounding the capillary, and buffer pH on the separation of some chiral basic drug substances in capillary zone electrophoresis has been evaluated. It was found that pH of the buffer and type and concentration of cyclodextrin had a major influence on the separation. (C) 1995 Wiley-Liss, Inc.

引用

页码：219 / 225

页数：7

共 12 条

[1] AMSTRONG DW, 1993, ANAL CHEM, V65, P1114
[2] AMSTRONG DW, 1994, ANAL CHEM, V66, P1473
[3] AMSTRONG DW, 1986, SCIENCE, V232, P1132
[4] BEREUTER T, 1994, LC GC EUR, V7, P78
[5] DALGLIESH CE, 1952, J CHEM SOC, V137, P3940
[6] PRACTICAL ASPECTS OF CHIRAL SEPARATIONS OF PHARMACEUTICALS BY CAPILLARY ELECTROPHORESIS .1. SEPARATION OPTIMIZATION
GUTTMAN, A
COOKE, N
[J]. JOURNAL OF CHROMATOGRAPHY A, 1994, 680 (01) : 157 - 162
[7] CAPILLARY ZONE ELECTROPHORESIS FOR SEPARATION OF DRUG ENANTIOMERS USING CYCLODEXTRINS AS CHIRAL SELECTORS - INFLUENCE OF EXPERIMENTAL PARAMETERS ON SEPARATION
PALMARSDOTTIR, S
EDHOLM, LE
[J]. JOURNAL OF CHROMATOGRAPHY A, 1994, 666 (1-2) : 337 - 350
[8] SYSTEMATIC-APPROACH TO TREATMENT OF ENANTIOMERIC SEPARATIONS IN CAPILLARY ELECTROPHORESIS AND LIQUID-CHROMATOGRAPHY .1. INITIAL EVALUATION USING PROPRANOLOL AND DANSYLATED AMINO-ACIDS
PENN, SG
LIU, GY
BERGSTROM, ET
GOODALL, DM
LORAN, JS
[J]. JOURNAL OF CHROMATOGRAPHY A, 1994, 680 (01) : 147 - 155
[9] CAPILLARY ELECTROPHORETIC CHIRAL SEPARATIONS USING BETA-CYCLODEXTRIN AS RESOLVING AGENT .2. BASES - CHIRAL SELECTIVITY AS A FUNCTION OF PH AND THE CONCENTRATION OF BETA-CYCLODEXTRIN
RAWJEE, YY
WILLIAMS, RL
VIGH, G
[J]. JOURNAL OF CHROMATOGRAPHY A, 1993, 652 (01) : 233 - 245
[10] TAIT RJ, 1993, 5 INT S HIGH PERF CA

← 1 2 →