EXPERIMENTAL VALIDATION OF RADIOPHARMACEUTICAL ABSORBED DOSE TO MINERALIZED BONE TISSUE

被引：21

作者：

DESROSIERS, MF ^{[1
]}

AVILA, MJ ^{[1
]}

SCHAUER, DA ^{[1
]}

COURSEY, BM ^{[1
]}

PARKS, NJ ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,ENERGY RELATED HLTH RES LAB,DAVIS,CA 95616

来源：

APPLIED RADIATION AND ISOTOPES | 1993年 / 44卷 / 1-2期

关键词：

BONE; CANCER; DOSIMETRY; MARROW; PHARMACEUTICAL; RADIONUCLIDE;

D O I：

10.1016/0969-8043(93)90267-E

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Therapeutic and palliative uses of bone-seeking radiopharmaceuticals are undergoing clinical trials for human subjects. Radiation dosimetry for these applications is based on the Medical Internal Radiation Dosimetry (MIRD) schema. An experimental method for dosimetry of bone tissue based on electron paramagnetic resonance (EPR) spectrometry is described. Preliminary results for beagle bone exposed to radiopharmaceuticals under clinical conditions have indicated that the EPR dose measurements give approximately the calculated dose, but suggest that the dose distribution may be non-uniform.

引用

页码：459 / 463

页数：5

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