FIBRONECTIN SYNTHESIS IN SUBRETINAL MEMBRANES OF PROLIFERATIVE VITREORETINOPATHY

被引：15

作者：

HISCOTT, P

WALLER, HA

GRIERSON, I

BUTLER, MG

SCOTT, DL

GREGOR, Z

MORINO, I

机构：

[1] ST BARTHOLOMEWS HOSP,DEPT CLIN SCI,LONDON EC1A 7BE,ENGLAND

[2] ST BARTHOLOMEWS HOSP,DEPT IMMUNOL,LONDON EC1A 7BE,ENGLAND

[3] ST BARTHOLOMEWS HOSP,DEPT RHEUMATOL,LONDON EC1A 7BE,ENGLAND

[4] MOORFIELDS EYE HOSP,VITREORETINAL UNIT,LONDON WC1V 7AN,ENGLAND

[5] KOBE UNIV,DEPT OPHTHALMOL,KOBE 657,JAPAN

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1992年 / 76卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/bjo.76.8.486

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In situ hybridisation and immunohistochemical studies were conducted on six surgically excised subretinal membranes of proliferative vitreoretinopathy to investigate whether displacement of retinal pigment epithelial and glial cells to subretinal membranes was associated with fibronectin production by the subretinal membrane cells. Fibronectin messenger RNA (mRNA) and fibronectin immunoreactivity were observed in some cells in all of the subretinal membranes studied and up to 30% of the cells in individual specimens showed intense labelling for fibronectin mRNA. The results support the concept that the cells in subretinal membranes produce fibronectin. Locally produced fibronectin may play a role in subretinal membrane cohesion, and displacement of retinal pigment epithelial and glial cells from their normal location may induce the cells to manufacture fibronectin. Fibronectin production may be more prominent in migrating subretinal cells.

引用

页码：486 / 490

页数：5

共 33 条

[21] DETECTION OF EXTRACELLULAR-MATRIX MOLECULES SYNTHESIZED INVITRO BY MONKEY AND HUMAN RETINAL-PIGMENT EPITHELIUM - INFLUENCE OF DONOR AGE AND MULTIPLE PASSAGES [J].