TYPE-2 CYTOKINES AND NEGATIVE IMMUNE REGULATION IN HUMAN INFECTIONS

被引：102

作者：

MODLIN, RL ^{[1
]}

NUTMAN, TB ^{[1
]}

机构：

[1] NIAID, PARASIT DIS LAB, BETHESDA, MD 20892 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0952-7915(93)90031-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that the human immune response to infection is regulated by the balance between the T helper type 1 cytokines. interleukin-2 and interferon-gamma, and the T helper type 2 cytokines. interleukin-4, interleukin-5 and interleukin-10. Interleukin-4 and interleukin-10 can facilitate antibody production but can also suppress cell-mediated immune responses. The net effect of these negative immunoregulatory cytokines is to favor progression of infection.

引用

页码：511 / 517

页数：7

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