AN ANTAGONIST OF GLUTAMATE METABOTROPIC RECEPTORS, (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE, PREVENTS THE LTP-RELATED INCREASE IN POSTSYNAPTIC AMPA SENSITIVITY IN HIPPOCAMPAL SLICES

被引：50

作者：

SERGUEEVA, OA ^{[1
]}

FEDOROV, NB ^{[1
]}

REYMANN, KG ^{[1
]}

机构：

[1] INST NEUROBIOL,DEPT NEUROPHYSIOL,BRENNECKESTR 6,POB 1860,D-39008 MAGDEBURG,GERMANY

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 09期

关键词：

METABOTROPIC GLUTAMATE RECEPTOR; MGLU-R; (RS)-ALPHA-METHYL-4-CARBOXYPHENYLGLYCINE; MCPG; LONG-TERM POTENTIATION; AMPA;

D O I：

10.1016/0028-3908(93)90150-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a compound which selectively antagonizes metabotrtopic glutamate receptors (mGlu-R), precents the LTP of field excitatory postsynaptic potentials (fEPSP) as well as the tetanus-induced increase in AMPA-evoked responses (fPRs) in the CA1 region of hippocampal slices. This effects of MCPG provide evidence for the involvement of mGlu-Rs in mechanisms underlying the postsynaptic maintenance of LTP, which appears to be mediated, at least partially, by an increase in sensitivity and/or number of postsynaptic AMPA receptors.

引用

页码：933 / 935

页数：3

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