IGG1 AND IGG4 ANTIBODY-RESPONSES TO THE DUST-MITE LEPIDOGLYPHUS-DESTRUCTOR IN A NATURALLY EXPOSED FARMING POPULATION

被引:8
作者
JOHANSSON, E
HARFAST, B
JOHANSSON, SGO
VANHAGEHAMSTEN, M
机构
[1] Department of Clinical Immunology, Division of Laboratory Medicine, Karolinska Hospital, Stockholm
关键词
ATOPIC PATIENTS; IGG7; IGG4; IMMUNOBLOTTING; LEPIDOGLYPHUS DESTRUCTOR; MITES;
D O I
10.1111/j.1398-9995.1995.tb01181.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The natural humoral immune response to the dust mite Lepidoglyphus destructor was assessed by comparing the IgG1 and IgG4 responses elicited in allergic (n = 44) and healthy (n = 16) individuals in a farming population chronically exposed to this allergen. With the aid of an immunoblotting technique and ELISA, the sera were analyzed for anti-L. destructor antibodies. While the majority of sera from the allergy group displayed several bands for both IgG1 and IgG4, the nonatopic healthy group was negative as analyzed in immunoblotting. When they were analyzed in ELISA, there was a significantly higher response in the allergy group than in the healthy group for 1gG4, but not for IgG1. Taken together, these results imply that the immune system of individuals spared from allergic reactions to L. destructor not only lacks IgE antibodies but also seems largely to ''ignore'' these allergens/antigens despite exposure.
引用
收藏
页码:473 / 477
页数:5
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