NISAMYCIN, A NEW MANUMYCIN GROUP ANTIBIOTIC FROM STREPTOMYCES SP K106 .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：16

作者：

HAYASHI, K ^{[1
]}

NAKAGAWA, M ^{[1
]}

NAKAYAMA, M ^{[1
]}

机构：

[1] UNIV OSAKA PREFECTURE,FAC AGR,DEPT AGR CHEM,SAKAI,OSAKA 593,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 10期

关键词：

D O I：

10.7164/antibiotics.47.1104

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nisamycin, a new manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. This strain was designated to genus Streptomyces by the taxonomic features. Nisamycin was purified by ethyl acetate extraction, silica gel column chromatography, preparative silica gel TLC, and Sephadex LH-20 column chromatography as a pale yellow powder. Nisamycin is active against Gram-positive bacteria and fungi, and exhibits a cytotoxic activity.

引用

页码：1104 / 1109

页数：6

共 15 条

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