NISAMYCIN, A NEW MANUMYCIN GROUP ANTIBIOTIC FROM STREPTOMYCES SP K106 .2. STRUCTURE DETERMINATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS

被引：15

作者：

HAYASHI, K ^{[1
]}

NAKAGAWA, M ^{[1
]}

FUJITA, T ^{[1
]}

TANIMORI, S ^{[1
]}

NAKAYAMA, M ^{[1
]}

机构：

[1] UNIV OSAKA PREFECTURE,FAC AGR,DEPT AGR CHEM,SAKAI,OSAKA 593,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 10期

关键词：

D O I：

10.7164/antibiotics.47.1110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nisamycin, a novel manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. Structural elucidation of nisamycin was achieved by detailed NMR spectral analyses and comparison of the NMR data of nisamycin with those of other manumycin group antibiotics. The structure was confirmed by chromic acid oxidation. The absolute stereochemistry of nisamycin was determined to be 4R, 5S and 6R from the CD spectra of nisamycin and chromic oxidation of nisamycin. In addition, some structure activity-relationships were examined.

引用

页码：1110 / 1115

页数：6

共 9 条

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