THE HUMAN PANCREATIC LIPASE-ENCODING GENE - STRUCTURE AND CONSERVATION OF AN ALU SEQUENCE IN THE LIPASE GENE FAMILY

被引：26

作者：

SIMS, HF ^{[1
]}

JENNENS, ML ^{[1
]}

LOWE, ME ^{[1
]}

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT PEDIAT, ST LOUIS, MO 63110 USA

来源：

GENE | 1993年 / 131卷 / 02期

关键词：

RECOMBINANT DNA; NUCLEOTIDE SEQUENCING; TRIGLYCERIDES; PHYLOGENY; CANINE; FLANKING SEQUENCES; INTRONS; PSEUDOGENE;

D O I：

10.1016/0378-1119(93)90307-O

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The isolation and characterization of the human gene (hPL) encoding pancreatic lipase is reported. The gene has 13 exons dispersed in about 20 kb of genomic DNA. A pseudogene of hPL was also partially characterized. An Alu sequence is conserved in the homologous introns of hPL and the lipoprotein lipase-encoding gene.

引用

页码：281 / 285

页数：5

共 18 条

[1] AMEIS D, 1990, J BIOL CHEM, V265, P6552
[2] CELL-SPECIFIC ENHANCERS IN THE RAT EXOCRINE PANCREAS
BOULET, AM
ERWIN, CR
RUTTER, WJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) : 3599 - 3603
[3] A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTER OF A TRIACYLGLYCEROL LIPASE
BRADY, L
BRZOZOWSKI, AM
DEREWENDA, ZS
DODSON, E
DODSON, G
TOLLEY, S
TURKENBURG, JP
CHRISTIANSEN, L
HUGEJENSEN, B
NORSKOV, L
THIM, L
MENGE, U
[J]. NATURE, 1990, 343 (6260) : 767 - 770
[4] STRUCTURE OF THE HUMAN HEPATIC TRIGLYCERIDE LIPASE GENE
CAI, SJ
WONG, DM
CHEN, SH
CHAN, L
[J]. BIOCHEMISTRY, 1989, 28 (23) : 8966 - 8971
[5] THE LIPOPROTEIN LIPASE-ENCODING HUMAN GENE - SEQUENCE FROM INTRON-6 TO INTRON-9 AND PRESENCE IN INTRON-7 OF A 40-MILLION-YEAR-OLD ALU SEQUENCE
CHUAT, JC
RAISONNIER, A
ETIENNE, J
GALIBERT, F
[J]. GENE, 1992, 110 (02) : 257 - 261
[6] STRUCTURE OF THE HUMAN LIPOPROTEIN-LIPASE GENE
DEEB, SS
PENG, RL
[J]. BIOCHEMISTRY, 1989, 28 (10) : 4132 - 4135
[7] GILLER T, 1992, J BIOL CHEM, V267, P16509
[8] A FUNDAMENTAL DIVISION IN THE ALU FAMILY OF REPEATED SEQUENCES
JURKA, J
SMITH, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (13) : 4775 - 4778
[9] RECONSTRUCTION AND ANALYSIS OF HUMAN ALU GENES
JURKA, J
MILOSAVLJEVIC, A
[J]. JOURNAL OF MOLECULAR EVOLUTION, 1991, 32 (02) : 105 - 121
[10] Kerfelec B, 1986, Pancreas, V1, P430, DOI 10.1097/00006676-198609000-00007

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