PROTEIN-INDUCED BENDING AS A TRANSCRIPTIONAL SWITCH

被引：69

作者：

PEREZMARTIN, J ^{[1
]}

ESPINOSA, M ^{[1
]}

机构：

[1] CSIC,CTR INVEST BIOL,VELAZQUEZ 144,E-28006 MADRID,SPAIN

来源：

SCIENCE | 1993年 / 260卷 / 5109期

关键词：

D O I：

10.1126/science.8387228

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The question of whether protein-induced DNA bending can act as a switch factor when placed upstream of an array of promoters located in tandem was investigated in vivo. The catabolite activating protein binding site of the fur operon was replaced by the binding site of the RepA repressor protein, which is able to bend DNA immediately after binding. Appropriately phased induced bending could act as a transcriptional switch factor in vivo.

引用

页码：805 / 807

页数：3

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