CANCER PREDISPOSITION - ATAXIA-TELANGIECTASIA AT THE CROSSROADS

被引：62

作者：

JACKSON, SP ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 1QR,ENGLAND

来源：

CURRENT BIOLOGY | 1995年 / 5卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(95)00238-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ATM, the gene product mutated in the cancer susceptibility syndrome ataxia-telangiectasia, is related to proteins involved in DNA repair and cell-cycle control, perhaps explaining how ATM prevents carcinogenesis.

引用

页码：1210 / 1212

页数：3

共 13 条

[1] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX
BROWN, EJ
ALBERS, MW
SHIN, TB
ICHIKAWA, K
KEITH, CT
LANE, WS
SCHREIBER, SL
[J]. NATURE, 1994, 369 (6483) : 756 - 758
[2] TEL1, A GENE INVOLVED IN CONTROLLING TELOMERE LENGTH IN SACCHAROMYCES-CEREVISIAE, IS HOMOLOGOUS TO THE HUMAN ATAXIA-TELANGIECTASIA GENE
GREENWELL, PW
KRONMAL, SL
PORTER, SE
GASSENHUBER, J
OBERMAIER, B
PETES, TD
[J]. CELL, 1995, 82 (05) : 823 - 829
[3] THE MEI-41 GENE OF DROSOPHILA-MELANOGASTER IS A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE HUMAN ATAXIA-TELANGIECTASIA GENE
HARI, KL
SANTERRE, A
SEKELSKY, JJ
MCKIM, KS
BOYD, JB
HAWLEY, RS
[J]. CELL, 1995, 82 (05) : 815 - 821
[4] DNA-DEPENDENT PROTEIN-KINASE CATALYTIC SUBUNIT - A RELATIVE OF PHOSPHATIDYLINOSITOL 3-KINASE AND THE ATAXIA-TELANGIECTASIA GENE-PRODUCT
HARTLEY, KO
GELL, D
SMITH, GCM
ZHANG, H
DIVECHA, N
CONNELLY, MA
ADMON, A
LEESMILLER, SP
ANDERSON, CW
JACKSON, SP
[J]. CELL, 1995, 82 (05) : 849 - 856
[5] DNA DOUBLE-STRAND BREAK REPAIR AND V(D)J RECOMBINATION - INVOLVEMENT OF DNA-PK
JACKSON, SP
JEGGO, PA
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (10) : 412 - 415
[6] CORRECTION OF RADIATION SENSITIVITY IN ATAXIA-TELANGIECTASIA CELLS BY A TRUNCATED I-KAPPA-B-ALPHA
JUNG, M
ZHANG, Y
LEE, S
DRITSCHILO, A
[J]. SCIENCE, 1995, 268 (5217) : 1619 - 1621
[7] PHOSPHATIDYLINOSITOL 3-KINASE
KAPELLER, R
CANTLEY, LC
[J]. BIOESSAYS, 1994, 16 (08) : 565 - 576
[8] A MAMMALIAN-CELL CYCLE CHECKPOINT PATHWAY UTILIZING P53 AND GADD45 IS DEFECTIVE IN ATAXIA-TELANGIECTASIA
KASTAN, MB
ZHAN, QM
ELDEIRY, WS
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JACKS, T
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PLUNKETT, BS
VOGELSTEIN, B
FORNACE, AJ
[J]. CELL, 1992, 71 (04) : 587 - 597
[9] TEL1, AN SACCHAROMYCES-CEREVISIAE HOMOLOG OF THE HUMAN GENE MUTATED IN ATAXIA-TELANGIECTASIA, IS FUNCTIONALLY RELATED TO THE YEAST CHECKPOINT GENE MEC1
MORROW, DM
MORROW, M
TAGLE, DA
SHILOH, Y
COLLINS, FS
HIETER, P
[J]. CELL, 1995, 82 (05) : 831 - 840
[10] A SINGLE ATAXIA-TELANGIECTASIA GENE WITH A PRODUCT SIMILAR TO PI-3 KINASE
SAVITSKY, K
BARSHIRA, A
GILAD, S
ROTMAN, G
ZIV, Y
VANAGAITE, L
TAGLE, DA
SMITH, S
UZIEL, T
SFEZ, S
ASHKENAZI, M
PECKER, I
FRYDMAN, M
HARNIK, R
PATANJALI, SR
SIMMONS, A
CLINES, GA
SARTIEL, A
GATTI, RA
CHESSA, L
SANAL, O
LAVIN, MF
JASPERS, NGJ
MALCOLM, A
TAYLOR, R
ARLETT, CF
MIKI, T
WEISSMAN, SM
LOVETT, M
COLLINS, FS
SHILOH, Y
[J]. SCIENCE, 1995, 268 (5218) : 1749 - 1753

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