IMMOBILIZATION OF PLASMINOGEN ON ESCHERICHIA-COLI FLAGELLA

被引：22

作者：

LAHTEENMAKI, K

WESTERLUND, B

KUUSELA, P

KORHONEN, TK

机构：

[1] UNIV HELSINKI, DEPT GEN MICROBIOL, MANNERHEIMINTIE 172, SF-00300 HELSINKI, FINLAND

[2] UNIV HELSINKI, DEPT BACTERIOL & IMMUNOL, SF-00100 HELSINKI 10, FINLAND

来源：

FEMS MICROBIOLOGY LETTERS | 1993年 / 106卷 / 03期

关键词：

ESCHERICHIA-COLI; FLAGELLA; PLASMINOGEN; PROTEOLYSIS;

D O I：

10.1016/0378-1097(93)90420-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interaction of plasminogen with flagella of Escherichia coli was investigated. Plasminogen bound to flagella purified from E. coli LE392, a commonly used cloning host, and E. coli IH3069, an O25H1 strain isolated from a case of newborn bacteremia. The binding was inhibited by the lysine analog epsilon-aminocaproic acid, suggesting involvement of the lysine-binding Kringle domains of plasminogen in the binding. Purified flagella enhanced the formation of plasmin activity in the presence of tissue-type plasminogen activator; a similar enhancement was observed with flagella-expressing LE392 cells.

引用

页码：309 / 314

页数：6

共 27 条

[1] FLAGELLA OF SALMONELLA-TYPHIMURIUM ARE A VIRULENCE FACTOR IN INFECTED C57BL/6J MICE [J].