H2O2-INDUCED LIPID-PEROXIDATION IN RAT-BRAIN HOMOGENATES IS GREATLY REDUCED BY MELATONIN

被引：51

作者：

SEWERYNEK, E

POEGGELER, B

MELCHIORRI, D

REITER, RJ

机构：

[1] UNIV TEXAS, HLTH SCI CTR, DEPT CELLULAR & STRUCT BIOL, SAN ANTONIO, TX 78284 USA

[2] UNIV LODZ, SCH MED, DEPT THYROIDOL, PL-91425 LODZ, POLAND

来源：

NEUROSCIENCE LETTERS | 1995年 / 195卷 / 03期

关键词：

MELATONIN; H2O2; HYDROXYL RADICAL; LIPID PEROXIDATION;

D O I：

10.1016/0304-3940(95)11803-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H2O2 (0.1-5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1-5 mM) protected against H2O2-induced lipid peroxidation of brain homogenates in a concentration-dependent manner.

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页码：203 / 205

页数：3

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