ACYLATION OF LYCOCTONINE - SEMISYNTHESIS OF INULINE, DELSEMINE ANALOGS AND METHYLLYCACONITINE

被引：34

作者：

BLAGBROUGH, IS

COATES, PA

HARDICK, DJ

LEWIS, T

ROWAN, MG

WONNACOTT, S

POTTER, BVL

机构：

[1] UNIV BATH,SCH BIOL & BIOCHEM,BATH BA2 7AY,AVON,ENGLAND

[2] ZENECA AGROCHEM,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)78477-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lycoctonine has been acylated to afford sequentially inuline, delsemine analogues and methyllycaconitine using isatoic anhydride followed by S-(-)-methylsuccinic anhydride. This protocol is a rapid, facile method for the regiospecific introduction of the anthranilate ester moiety found in potent nicotinic acetylcholine receptor antagonists.

引用

页码：8705 / 8708

页数：4

共 20 条

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