A RANDOM-WALK GIANT-LOOP MODEL FOR INTERPHASE CHROMOSOMES

被引：259

作者：

SACHS, RK

VANDENENGH, G

TRASK, B

YOKOTA, H

HEARST, JE

机构：

[1] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

[2] UNIV WASHINGTON,DEPT MOLEC BIOTECHNOL,SEATTLE,WA 98195

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 07期

关键词：

CHROMATIN; FLUORESCENT IN SITU HYBRIDIZATION; CELL NUCLEUS ULTRASTRUCTURE; POLYMERS;

D O I：

10.1073/pnas.92.7.2710

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fluorescence in situ hybridization data on distances between defined genomic sequences are used to construct a quantitative model for the overall geometric structure of a human chromosome. We suggest that the large-scale geometry during the G(0)/G(1) part of the cell cycle may consist of flexible chromatin loops, averaging approximate to 3 million bp, with a random-walk backbone. A fully explicit, three-parametric polymer model of this random-walk/giant-loop structure can account well for the data, More general models consistent with the data are briefly discussed.

引用

页码：2710 / 2714

页数：5

共 17 条

[11] DELINEATION OF INDIVIDUAL HUMAN-CHROMOSOMES IN METAPHASE AND INTERPHASE CELLS BY INSITU SUPPRESSION HYBRIDIZATION USING RECOMBINANT DNA LIBRARIES [J].