HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF DERIVATIZED AMINO-ACIDS ENANTIOMERS USING MODIFIED BETA-CYCLODEXTRIN AS A MOBILE-PHASE ADDITIVE

被引：7

作者：

SPENCER, BJ ^{[1
]}

PURDY, WC ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA

来源：

ANALYTICAL LETTERS | 1995年 / 28卷 / 10期

关键词：

CYCLODEXTRINS; DERIVATIZED AMINO ACID ENANTIOMERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1080/00032719508000363

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Derivatized beta-cyclodextrin was used as a mobile phase additive for the liquid chromatographic resolution of amino acid derivative enantiomers with an achiral C-18 stationary phase. The separation and retention obtained with methyl-beta-cyclodextrin was compared with that of the unmodified beta-cyclodextrin at different mobile phase compositions. The effects of cyclodextrin concentration, pH, and methanol and buffer concentration on enantioselectivity and capacity factor were examined.

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页码：1865 / 1881

页数：17

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