NEOCLERODANE AND SECO-NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM-GRACILE AND T-FRUTICANS

被引：21

作者：

BRUNO, M

ALCAZAR, R

DELATORRE, MC

PIOZZI, F

RODRIGUEZ, B

SAVONA, G

PERALES, A

ARNOLD, NA

机构：

[1] CSIC,INST QUIM ORGAN,E-28006 MADRID,SPAIN

[2] CSIC,DEPT RAYOS-X,E-28006 MADRID,SPAIN

[3] UNIV CAMERINO,IST BOT FARMACEUT,I-62032 CAMERINO,ITALY

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 10期

关键词：

TEUCRIUM-GRACILE; T-FRUTICANS; LABIATAE; NEOCLERODANE DITERPENES; 5,6-SECO-NEO-CLERODANE DERIVATIVE; TEUGRACILIN-D AND TEUGRACILIN-E; FRUTICOLIDE;

D O I：

10.1016/0031-9422(92)83722-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new neo-clerodane diterpenoids, teugracilins D and E, together with the previously known diterpene 19-acetylteulepicin, have been isolated from Teucrium gracile. The structures of teugracilin D [19-acetoxy-4alpha,18;15, 16-diepoxy-3beta,6alpha-dihydroxy-neo-cleroda-13(16),14-diene-(20-O-acetyl)-20R,12S-hemiacetal] and teugracilin E [3beta,6alpha,12zeta,19,20-pentaacetoxy-4alpha,18;15,16-diepoxy-neo-cleroda-13(16),14-diene] were determined on spectroscopic grounds. In addition, reexamination of the diterpene composition of T. fruticans allowed the isolation, for the first time from Teucrium species, of a new seco-neo-clerodane derivative, fruticolide. Its structure, 19-acetoxy-4alpha,18;15, 16-diepoxy-5,6-seco-neo-cleroda-13(16),14-dien-6,1alpha-olide, was established by spectroscopic means, including an X-ray diffraction analysis.

引用

页码：3531 / 3534

页数：4

共 17 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2] NEOCLERODANE DITERPENOIDS FROM TEUCRIUM-GRACILE [J].

BRUNO, M ;

DOMINGUEZ, G ;

LOURENCO, A ;

PIOZZI, F ;

RODRIGUEZ, B ;

SAVONA, G ;

DELATORRE, MC ;

ARNOLD, NA .

PHYTOCHEMISTRY, 1991, 30 (11) :3693-3697

[3] TEUCROLIVINS-D-F, NEOCLERODANE DERIVATIVES FROM TEUCRIUM-OLIVERIANUM [J].

DELATORRE, MC ;

BRUNO, M ;

PIOZZI, F ;

SAVONA, G ;

RODRIGUEZ, B ;

OMAR, AA .

PHYTOCHEMISTRY, 1991, 30 (05) :1603-1606

[4] 2 NEOCLERODANE DITERPENOIDS CONTAINING AN UNUSUAL 2,6-DIOXABICYCLO[2.2.1]HEPTANE STRUCTURAL MOIETY [J].

DELATORRE, MC ;

BRUNO, M ;

PIOZZI, F ;

SAVONA, G ;

OMAR, AA ;

PERALES, A ;

RODRIGUEZ, B .

TETRAHEDRON, 1991, 47 (20-21) :3463-3470

[5] NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM-MICROPODIOIDES [J].

DELATORRE, MC ;

RODRIGUEZ, B ;

BRUNO, M ;

SAVONA, G ;

PIOZZI, F ;

SERVETTAZ, O .

PHYTOCHEMISTRY, 1988, 27 (01) :213-216

[6] NEO-CLERODANE DITERPENOIDS FROM TEUCRIUM-PYRENAICUM [J].

GARCIAALVAREZ, MC ;

MARCO, JL ;

RODRIGUEZ, B ;

SAVONA, G ;

PIOZZI, F .

PHYTOCHEMISTRY, 1982, 21 (10) :2559-2562

[7]

JOHNSON CK, 1976, ORNL5138 REP

[8]

MAIN P, 1980, MULTAN SYSTEM COMPUT

[9]

MARTINEZRIPOLL M, 1977, CONFAB

[10] THE C-12 AND C-20 CONFIGURATIONS OF SOME NEOCLERODANE DITERPENOIDS ISOLATED FROM TEUCRIUM SPECIES [J].

PASCUAL, C ;

FERNANDEZ, P ;

GARCIAALVAREZ, MC ;

MARCO, JL ;

FERNANDEZGADEA, F ;

DELATORRE, MC ;

HUESORODRIGUEZ, JA ;

RODRIGUEZ, B ;

BRUNO, M ;

PATERNOSTRO, M ;

PIOZZI, F ;

SAVONA, G .

PHYTOCHEMISTRY, 1986, 25 (03) :715-718

← 1 2 →