STRUCTURE AND METABOLISM OF LIPOPROTEIN (A)

被引：50

作者：

MARCOVINA, SM

MORRISETT, JD

机构：

[1] UNIV WASHINGTON,DEPT MED,NW LIPID RES LABS,SEATTLE,WA 98103

[2] BAYLOR COLL MED,DEPT MED,DIV ATHEROSCLEROSIS & LIPOPROT RES,HOUSTON,TX

来源：

CURRENT OPINION IN LIPIDOLOGY | 1995年 / 6卷 / 03期

关键词：

D O I：

10.1097/00041433-199506000-00005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An understanding of the complex structural and metabolic features of lipoprotein (a) is essential because this lipoprotein particle, with poorly recognized physiological functions, has been implicated in both thrombogenesis and atherogenesis. Studies aimed at investigating the structure-function relationship of apolipoprotein (a) have generated new useful information. In-vivo and in-vitro studies have provided insights into the synthesis, secretion, and association of apolipoprotein (a) with apolipoprotein B-100 and the mechanisms regulating the lipoprotein (a) concentration in the bloodstream.

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页码：136 / 145

页数：10

相关论文

共 56 条

[1] ISOLATION AND CHARACTERIZATION OF 2 SUBSPECIES OF LP(A), ONE CONTAINING APO-E AND ONE FREE OF APO-E [J].

BARD, JM ;

DELATTRELESTAVEL, S ;

CLAVEY, V ;

PONT, P ;

DERUDAS, B ;

PARRA, HJ ;

FRUCHART, JC .

BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1127 (02) :124-130

[2] FAT FEEDING IN HUMANS INDUCES LIPOPROTEINS OF DENSITY LESS THAN 1.006 THAT ARE ENRICHED IN APOLIPOPROTEIN [A] AND THAT CAUSE LIPID-ACCUMULATION IN MACROPHAGES [J].

BERSOT, TP ;

INNERARITY, TL ;

PITAS, RE ;

RALL, SC ;

WEISGRABER, KH ;

MAHLEY, RW .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (02) :622-630

[3] IDENTIFICATION AND QUANTIFICATION OF APOLIPOPROTEINS IN ADDITION TO APO[A] AND APO B-100 IN HUMAN LIPOPROTEIN[A] [J].

BLANCOVACA, F ;

GAUBATZ, JW ;

BREN, N ;

KOTTKE, BA ;

MORRISETT, JD ;

GUEVARA, J .

CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 67-8 :35-42

[4]

BOTTALICO LA, 1993, J BIOL CHEM, V268, P8569

[5] CYS4057 OF APOLIPOPROTEIN(A) IS ESSENTIAL FOR LIPOPROTEIN(A) ASSEMBLY [J].

BRUNNER, C ;

KRAFT, HG ;

UTERMANN, G ;

MULLER, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) :11643-11647

[6] EXPRESSION OF HUMAN APOLIPOPROTEIN-B AND ASSEMBLY OF LIPOPROTEIN(A) IN TRANSGENIC MICE [J].

CALLOW, MJ ;

STOLTZFUS, LJ ;

LAWN, RM ;

RUBIN, EM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (06) :2130-2134

[7] PARTIAL AMINO-ACID-SEQUENCE OF APOLIPOPROTEIN(A) SHOWS THAT IT IS HOMOLOGOUS TO PLASMINOGEN [J].

EATON, DL ;

FLESS, GM ;

KOHR, WJ ;

MCLEAN, JW ;

XU, QT ;

MILLER, CG ;

LAWN, RM ;

SCANU, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (10) :3224-3228

[8] OLEATE STIMULATES THE FORMATION OF TRIGLYCERIDE-RICH PARTICLES CONTAINING APOB100-APO(A) IN LONG-TERM PRIMARY CULTURES OF HUMAN HEPATOCYTES [J].

EDELSTEIN, C ;

DAVIDSON, NO ;

SCANU, AM .

CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 67-8 :135-143

[9] POLYMORPHIC FORMS OF LP(A) WITH DIFFERENT STRUCTURAL AND FUNCTIONAL-PROPERTIES - COLD-INDUCED SELF-ASSOCIATION AND BINDING TO FIBRIN AND LYSINE-SEPHAROSE [J].

FLESS, GM ;

SNYDER, ML .

CHEMISTRY AND PHYSICS OF LIPIDS, 1994, 67-8 :69-79

[10]

FLESS GM, 1990, J LIPID RES, V31, P909

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