EFFICACY OF D-CPPENE, A COMPETITIVE N-METHYL-D-ASPARTATE ANTAGONIST IN FOCAL CEREBRAL-ISCHEMIA IN THE RAT

被引：32

作者：

PARK, CK ^{[1
]}

MCCULLOCH, J ^{[1
]}

KANG, JK ^{[1
]}

CHOI, CR ^{[1
]}

机构：

[1] CATHOLIC UNIV,COLL MED,DEPT NEUROSURG,SEOUL,SOUTH KOREA

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 01期

关键词：

FOCAL CEREBRAL ISCHEMIA; GLUTAMATE; N-METHYL-D-ASPARTATE ANTAGONIST; NEUROPROTECTION;

D O I：

10.1016/0304-3940(92)90770-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of a novel and potent competitive N-methyl-D-aspartate (NMDA) antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPPene) upon ischemic brain damage has been examined in a rat model of focal cerebral ischemia. Focal cerebral ischemia was produced by permanent occlusion of the left middle cerebral artery (MCA). The animals were sacrificed 24 h after MCA occlusion and the amount of ischemic brain damage was assessed at 8 predetermined coronal planes. Pretreatment with D-CPPene (1.5. 4.5 or 15 mg/kg, i.v.), initiated 15 min prior to MCA occulusion (followed by constant infusion at 1, 3 or 10 mg/kg/h), produced dose-dependent reductions in the volumes of infarction; the dose of 4.5 mg/kg being the most effective (reduced by 37%: P<0.01). These results indicate that systemic administration of the competitive NMDA antagonist D-CPPene has neuroprotective effects in a model of focal cerebral ischemia and define the dose dependency of its neuroprotective effects.

引用

页码：41 / 44

页数：4

共 22 条

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