EFFECTS OF NEOPTERIN ON ISCHEMIC NEURONAL DAMAGE IN GERBILS

被引：7

作者：

ARAI, T

WATANABE, K

NAKAO, S

MORI, H

MURAKAWA, M

MORI, K

TOOYAMA, I

KIMURA, H

KOJIMA, S

机构：

[1] SHIGA UNIV MED SCI,MOLEC NEUROBIOL RES CTR,SHIGA,JAPAN

[2] SCI UNIV TOKYO,BIOSCI RES INST,CHIBA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1994年 / 173卷 / 1-2期

关键词：

NEOPTERIN; CEREBRAL ISCHEMIA; OXYGEN FREE RADICAL; ISCHEMIC INJURY; HIPPOCAMPUS; MICROTUBULE-ASSOCIATED PROTEIN 2;

D O I：

10.1016/0304-3940(94)90160-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of neopterin on ischemic neuronal damage were examined. Cerebral ischemia was produced in the gerbil by bilateral common carotid occlusion for 8 min or unilateral occlusion for 30 min. which resulted in delayed neuronal death in the CA1 region of the hippocampus. However, preischemic treatment with neopterin (3 mg/kg i.p.) markedly reduced hippocampal neuronal damages in both cases, Since neopterin serves both as an antioxidant and as an oxidant depending on its redox state, these findings indicate that neopterin attenuates the ischemic neuronal injury by scavenging oxygen free radicals and/or by inhibiting their generation.

引用

页码：107 / 110

页数：4

共 18 条

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