COMPARISON OF THE INHIBITION OF METHOTREXATE-SENSITIVE AND METHOTREXATE-RESISTANT LACTOBACILLUS-CASEI CELL-CULTURES WITH PURIFIED LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE BY 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-(3-SUBSTITUTED-PHENYL)-S-TRIAZINES - USE OF QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS IN MAKING INFERENCES ABOUT THE MECHANISM OF RESISTANCE AND THE STRUCTURE OF THE ENZYME INSITU COMPARED WITH THE ENZYME INVITROUA

被引：31

作者：

COATS, EA ^{[1
]}

GENTHER, CS ^{[1
]}

DIETRICH, SW ^{[1
]}

GUO, Z ^{[1
]}

HANSCH, C ^{[1
]}

机构：

[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 12期

关键词：

D O I：

10.1021/jm00144a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1422 / 1429

页数：8

共 32 条

[1] PERMEABILIZATION OF ANIMAL-CELLS FOR KINETIC STUDIES OF INTRACELLULAR ENZYMES - INSITU BEHAVIOR OF THE GLYCOLYTIC-ENZYMES OF ERYTHROCYTES
ARAGON, JJ
FELIU, JE
FRENKEL, RA
SOLS, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (11): : 6324 - 6328
[2] DIHYDROFOLATE-REDUCTASE INHIBITION BY 2,4-DIAMINOTRIAZINES - STRUCTURE-ACTIVITY STUDY
DIETRICH, SW
SMITH, RN
FUKUNAGA, JY
OLNEY, M
HANSCH, C
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) : 600 - 611
[3] CONFIDENCE-INTERVAL ESTIMATORS FOR PARAMETERS ASSOCIATED WITH QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS
DIETRICH, SW
DREYER, ND
HANSCH, C
BENTLEY, DL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) : 1201 - 1205
[4] QUANTITATIVE STRUCTURE-SELECTIVITY RELATIONSHIPS - COMPARISON OF THE INHIBITION OF ESCHERICHIA-COLI AND BOVINE LIVER DIHYDROFOLATE-REDUCTASE BY 5-(SUBSTITUTED-BENZYL)-2,4-DIAMINOPYRIMIDINES
DIETRICH, SW
BLANEY, JM
REYNOLDS, MA
JOW, PYC
HANSCH, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1980, 23 (11) : 1205 - 1212
[5] USE OF TRIAZINE INHIBITORS IN MAPPING THE ACTIVE-SITE REGION OF LACTOBACILLUS-CASEI DIHYDROFOLATE-REDUCTASE
DIETRICH, SW
SMITH, RN
BRENDLER, S
HANSCH, C
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1979, 194 (02) : 612 - 619
[6] MEDIUM FOR ASSAY OF VITAMINS WITH LACTIC ACID BACTERIA
FLYNN, LM
WILLIAMS, VB
ODELL, BL
HOGAN, AG
[J]. ANALYTICAL CHEMISTRY, 1951, 23 (01) : 180 - 185
[7] FRIEDEN C, 1967, J BIOL CHEM, V242, P1705
[8] INHIBITION OF DIHYDROFOLATE-REDUCTASE - STRUCTURE-ACTIVITY CORRELATIONS OF QUINAZOLINES
FUKUNAGA, JY
HANSCH, C
STELLER, EE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (05) : 605 - 611
[9] GRECO WR, 1980, J PHARM EXP THER, V39, P212
[10] GUO ZR, MOL PHARM

← 1 2 3 4 →