AVERMECTIN ANALOGS WITH A SPACER BETWEEN THE AGLYCONE AND THE DISACCHARIDE

被引：12

作者：

BLIZZARD, T

MARGIATTO, G

LINN, B

MROZIK, H

FISHER, M

机构：

[1] Merck Sharp and Dohme Research Laboratories R5OG-231, Rahway, NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80475-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ivermectin (1) has been converted to several analogs in which a spacer unit has been inserted between the aglycone and the disaccharide. Analogs 9 and 10 retain good bioactivity while analogs 15, 16, 21, and 22 are substantially less active than 1.

引用

页码：369 / 372

页数：4

共 23 条

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