De novo protein design: what are we learning?

被引：70

作者：

DeGrado, William F. ^{[1
]}

Raleigh, Daniel P. ^{[1
]}

Handel, Tracey ^{[1
]}

机构：

[1] Du Pont Merck Pharmaceut Co, Du Pont Expt Stn, POB 80328, Wilmington, DE 19880 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1991年 / 1卷 / 06期

关键词：

D O I：

10.1016/0959-440X(91)90095-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of de novo design is examined in the light of current theories of protein folding. The most carefully characterized designed proteins show many of the characteristics of molten globules or protein folding intermediates. Thus, it is unclear whether or not the objective of designing proteins that fully mimic the native states of natural proteins has been achieved.

引用

页码：984 / 993

页数：10

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