EVIDENCE AGAINST A PRESYNAPTIC MECHANISM FOR KAINATE NEUROTOXICITY IN THE COCHLEAR NUCLEUS

被引：31

作者：

BIRD, SJ

GULLEY, RL

机构：

[1] CASE WESTERN RESERVE UNIV,DEPT ANAT,CLEVELAND,OH 44106

[2] UNIV TEXAS,HLTH SCI CTR,DEPT ANAT,SAN ANTONIO,TX 78284

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)91529-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kainic acid produces a selective pattern of degeneration in the cochlear nucleus of the guinea pig. This pattern is not altered by destruction of the putative glutamatergic primary afferent innervation, even with minimal doses of kainic acid. Thus, kainate neurotoxicity does not require intact presynaptic terminals in the cochlear nucleus. © 1979.

引用

收藏

页码：55 / 60

页数：6

相关论文

共 28 条

[1] KAINIC ACID INJECTIONS RESULT IN DEGENERATION OF COCHLEAR NUCLEUS CELLS INNERVATED BY AUDITORY-NERVE [J].

BIRD, SJ ;

GULLEY, RL ;

WENTHOLD, RJ .

SCIENCE, 1978, 202 (4372) :1087-1089

[2] D-ALPHA-AMINOADIPATE, ALPHA,EPSILON-DIOMINOPIMELIC ACID AND HA-966 AS ANTAGONISTS OF AMINO ACID-INDUCED AND SYNAPTIC EXCITATION OF MAMMALIAN SPINAL NEURONS INVIVO [J].

BISCOE, TJ ;

DAVIES, J ;

DRAY, A ;

EVANS, RH ;

MARTIN, MR ;

WATKINS, JC .

BRAIN RESEARCH, 1978, 148 (02) :543-548

[3] D-ALPHA-AMINOADIPATE AS A SELECTIVE ANTAGONIST OF AMINO ACID-INDUCED AND SYNAPTIC EXCITATION OF MAMMALIAN SPINAL NEURONS [J].

BISCOE, TJ ;

EVANS, RH ;

FRANCIS, AA ;

MARTIN, MR ;

WATKINS, JC .

NATURE, 1977, 270 (5639) :743-745

[4] INFLUENCE OF CORTICO-STRIATAL AFFERENTS ON STRIATAL KAINIC ACID NEUROTOXICITY [J].

BIZIERE, K ;

COYLE, JT .

NEUROSCIENCE LETTERS, 1978, 8 (04) :303-310

[5] LESION OF STRIATAL NEURONS WITH KAINIC ACID PROVIDES A MODEL FOR HUNTINGTONS-CHOREA [J].

COYLE, JT ;

SCHWARCZ, R .

NATURE, 1976, 263 (5574) :244-246

[6] SPECIFIC ANTAGONISM OF EXCITANT AMINO-ACIDS IN ISOLATED SPINAL-CORD OF NEONATAL RAT [J].

EVANS, RH ;

WATKINS, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1978, 50 (02) :123-129

[7] INTERNAL ORGANIZATION OF MEMBRANES AT END BULBS OF HELD IN ANTEROVENTRAL COCHLEAR NUCLEUS [J].

GULLEY, RL ;

LANDIS, DMD ;

REESE, TS .

JOURNAL OF COMPARATIVE NEUROLOGY, 1978, 180 (04) :707-+

[8] KAINIC ACID AND GLUTAMATE RECEPTOR [J].

HALL, JG ;

HICKS, TP ;

MCLENNAN, H .

NEUROSCIENCE LETTERS, 1978, 8 (02) :171-175

[9] FINE-STRUCTURAL CHANGES IN RAT STRIATUM AFTER LOCAL INJECTIONS OF KAINIC ACID [J].

HATTORI, T ;

MCGEER, EG .

BRAIN RESEARCH, 1977, 129 (01) :174-180

[10] L-GLUTAMATE SPECIFIC [H-3] KAINIC ACID BINDING IN THE RAT NEOSTRIATUM AFTER DEGENERATION OF THE CORTICO-STRIATAL PATHWAY [J].

HENKE, H ;

CUENOD, M .

NEUROSCIENCE LETTERS, 1979, 11 (03) :341-345