GENOMIC ORGANIZATION OF THE HUMAN FOLATE RECEPTOR GENES ON CHROMOSOME-11Q13

被引:69
作者
RAGOUSSIS, J
SENGER, G
TROWSDALE, J
CAMPBELL, IG
机构
[1] IMPERIAL CANC RES FUND,HUMAN IMMUNOGENET LAB,POB 123,44 LINCOLNS INN FIELDS,LONDON WC2A 3PX,ENGLAND
[2] IMPERIAL CANC RES FUND,CYTOGENET LABS,LONDON WC2A 3PX,ENGLAND
关键词
D O I
10.1016/S0888-7543(05)80236-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
There has been interest in the high affinity folate receptor (FOLR) recently because of its high expression in the majority of ovarian tumors. The FOLR genes are part of a family that includes an adult gene, a fetal gene, and one or more pseudogenes, which have been localized to chromosome 11. As a step toward understanding why the adult FOLR gene product is expressed on tumors, we have determined the organization of all the human FOLR-related genes. YAC clones were isolated using the adult FOLR probe. The organization of the locus was determined by PFGE of YAC DNA and by YAC fragmentation. Four FOLR-related genes were found within 140 kb. The adult and fetal genes are not more than 23 kb apart, with the 3′ end of the adult gene facing the 5′ of the fetal gene. A physical map of over 900 kb of the surrounding region was also constructed. The chromosomal assignment of the FOLR locus was refined to 11q13.3-q13.5 telomeric of the FGF3 locus using fluorescence in situ hybridization. © 1992 Academic Press, Inc. All rights reserved.
引用
收藏
页码:423 / 430
页数:8
相关论文
共 27 条
  • [21] CLONING OF THE HLA CLASS-II REGION IN YEAST ARTIFICIAL CHROMOSOMES
    RAGOUSSIS, J
    MONACO, A
    MOCKRIDGE, I
    KENDALL, E
    CAMPBELL, RD
    TROWSDALE, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3753 - 3757
  • [22] HOMOLOGOUS MEMBRANE FOLATE BINDING-PROTEINS IN HUMAN-PLACENTA - CLONING AND SEQUENCE OF A CDNA
    RATNAM, M
    MARQUARDT, H
    DUHRING, JL
    FREISHEIM, JH
    [J]. BIOCHEMISTRY, 1989, 28 (20) : 8249 - 8254
  • [23] A NOVEL, RAPID METHOD FOR THE ISOLATION OF TERMINAL SEQUENCES FROM YEAST ARTIFICIAL CHROMOSOME (YAC) CLONES
    RILEY, J
    BUTLER, R
    OGILVIE, D
    FINNIEAR, R
    JENNER, D
    POWELL, S
    ANAND, R
    SMITH, JC
    MARKHAM, AF
    [J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (10) : 2887 - 2890
  • [24] ROSENBERG CL, 1991, ONCOGENE, V6, P449
  • [25] SADASIVAN E, 1991, FED AM SOC EXP BIOL, pA1355
  • [26] SRIVATSAN ES, 1991, AM J HUM GENET, V49, P868
  • [27] FINE MAPPING OF PROBES IN THE ADENOMATOUS POLYPOSIS-COLI REGION OF CHROMOSOME-5 BY INSITU HYBRIDIZATION
    WILLIAMS, SV
    JONES, TA
    COTTRELL, S
    ZEHETNER, G
    VARESCO, L
    WARD, T
    THOMAS, H
    LAWSON, PA
    SOLOMON, E
    BODMER, WF
    FRISCHAUF, AM
    SHEER, D
    [J]. GENES CHROMOSOMES & CANCER, 1991, 3 (05) : 382 - 389