LIPOPOLYSACCHARIDE PRIMES HUMAN BASOPHILS FOR ENHANCED MEDIATOR RELEASE - REQUIREMENT FOR PLASMA COFACTOR AND CD14

被引：12

作者：

IIDA, M ^{[1
]}

HIRAI, K ^{[1
]}

SHINOHARA, S ^{[1
]}

YAMAGUCHI, M ^{[1
]}

TAKAISHI, T ^{[1
]}

SAKAMOTO, Y ^{[1
]}

ITO, K ^{[1
]}

MORITA, Y ^{[1
]}

机构：

[1] SAITAMA MED SCH,DEPT INTERNAL MED 2,MOROYAMA,SAITAMA 35004,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipopolysaccharide (LPS) is known to enhance IgE-mediated basophil degranulation. Recently, the complex of LPS and plasma LPS-binding protein(LBP) has been shown to induce secretory response via CD14 in monocytes and neutrophils. In the current study, we observed that the sensitivity to LPS of basophils was increased to 100-fold by co-incubation with plasma. LPS promptly completed its effect and amplified degranulation by stimuli bypassing IgE-receptors. Treatment with anti-CD14 completely abolished the priming effect of LPS. These results indicate that the priming effect of LPS on basophil mediator release is mediated via CD14, and that plasma co-factor, possibly identical to LBP, potentiates this reaction. (C) 1994 Academic Press, Inc.

引用

页码：1295 / 1301

页数：7

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