BELLIDIFOLIN STIMULATES GLUCOSE-UPTAKE IN RAT-1 FIBROBLASTS AND AMELIORATES HYPERGLYCEMIA IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC RATS

被引：52

作者：

BASNET, P

KADOTA, S

SHIMIZU, M

TAKATA, Y

KOBAYASHI, M

NAMBA, T

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,TOYAMA 93001,JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,TOYAMA 93001,JAPAN

[3] TOYAMA MED & PHARMACEUT UNIV,DEPT MED 1,TOYAMA 93001,JAPAN

来源：

PLANTA MEDICA | 1995年 / 61卷 / 05期

关键词：

SWERTIA JAPONICA; GENTIANACEAE; BELLIDIFOLIN; HYPOGLYCEMIC ACTIVITY; GLUCOSE UPTAKE ACTIVITY; RAT; 1; FIBROBLASTS;

D O I：

10.1055/s-2006-958124

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bellidifolin, isolated from Swertia japonica, was found to be a potent hypoglycemic agent in STZ-induced diabetic rats by both oral and intraperitoneal administration. Bellidifolin significantly lowered the loaded glucose level in normal as well as diabetic rats. Bellidifolin also lowered blood triglyceride levels significantly. It stimulated glucose uptake activity in Rat 1 fibroblasts expressing human insulin receptors.

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页码：402 / 405

页数：4

相关论文

共 14 条

[1] BIGUANIDES AND NIDDM [J].

BAILEY, CJ .

DIABETES CARE, 1992, 15 (06) :755-772

[2] THE HYPOGLYCEMIC ACTIVITY OF SWERTIA-JAPONICA EXTRACT IN STREPTOZOTOCIN-INDUCED HYPERGLYCEMIC RATS [J].

BASNET, P ;

KADOTA, S ;

NAMBA, T ;

SHIMIZU, M .

PHYTOTHERAPY RESEARCH, 1994, 8 (01) :55-57

[3] BELLIDIFOLIN - A POTENT HYPOGLYCEMIC AGENT IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC RATS FROM SWERTIA-JAPONICA [J].

BASNET, P ;

KADOTA, S ;

SHIMIZU, M ;

NAMBA, T .

PLANTA MEDICA, 1994, 60 (06) :507-511

[4]

BASNET P, 1994, IN PRESS J TRAD MED

[5] SULFONYLUREA-STIMULATED GLUCOSE-TRANSPORT ASSOCIATION WITH DIACYLGLYCEROLLIKE ACTIVATION OF PROTEIN-KINASE-C IN BC3H1 MYOCYTES [J].

COOPER, DR ;

VILA, MC ;

WATSON, JE ;

NAIR, G ;

POLLET, RJ ;

STANDAERT, M ;

FARESE, RV .

DIABETES, 1990, 39 (11) :1399-1407

[6] SULFONYLUREAS ACTIVATE GLUCOSE-TRANSPORT AND PROTEIN-KINASE-C IN RAT ADIPOCYTES [J].

FARESE, RV ;

ISHIZUKA, T ;

STANDAERT, ML ;

COOPER, DR .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1991, 40 (02) :196-200

[7]

GILMAN AG, 1990, PHARMACOL BASIS THER, P1484

[8] BIGUANIDES AND SULFONYLUREAS AS COMBINATION THERAPY IN NIDDM [J].

HERMANN, LS .

DIABETES CARE, 1990, 13 :37-41

[9] DIABETOGENIC ACTION OF STREPTOZOTOCIN - RELATIONSHIP OF DOSE TO METABOLIC RESPONSE [J].

JUNOD, A ;

LAMBERT, AE ;

STAUFFACHER, W ;

RENOLD, AE .

JOURNAL OF CLINICAL INVESTIGATION, 1969, 48 (11) :2129-+

[10] STREPTOZOTOCIN-INDUCED PANCREATIC INSULITIS - NEW MODEL OF DIABETES-MELLITUS [J].

LIKE, AA ;

ROSSINI, AA .

SCIENCE, 1976, 193 (4251) :415-417