A MUTATION IN THE INSULIN-RECEPTOR GENE THAT IMPAIRS TRANSPORT OF THE RECEPTOR TO THE PLASMA-MEMBRANE AND CAUSES INSULIN-RESISTANT DIABETES

被引:145
作者
ACCILI, D
FRAPIER, C
MOSTHAF, L
MCKEON, C
ELBEIN, SC
PERMUTT, MA
RAMOS, E
LANDER, E
ULLRICH, A
TAYLOR, SI
机构
[1] GENENTECH INC,S SAN FRANCISCO,CA 94080
[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110
[3] UNIV MARYLAND,DEPT INTERNAL MED,BALTIMORE,MD 21201
[4] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142
[5] HARVARD UNIV,CAMBRIDGE,MA 02138
关键词
D O I
10.1002/j.1460-2075.1989.tb08388.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:2509 / 2517
页数:9
相关论文
共 53 条
  • [51] DELETION IN CYSTEINE-RICH REGION OF LDL RECEPTOR IMPEDES TRANSPORT TO CELL-SURFACE IN WHHL RABBIT
    YAMAMOTO, T
    BISHOP, RW
    BROWN, MS
    GOLDSTEIN, JL
    RUSSELL, DW
    [J]. SCIENCE, 1986, 232 (4755) : 1230 - 1237
  • [52] GROWTH-FACTOR RECEPTOR TYROSINE KINASES
    YARDEN, Y
    ULLRICH, A
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 : 443 - 478
  • [53] INSULIN-RESISTANT DIABETES DUE TO A POINT MUTATION THAT PREVENTS INSULIN PRORECEPTOR PROCESSING
    YOSHIMASA, Y
    SEINO, S
    WHITTAKER, J
    KAKEHI, T
    KOSAKI, A
    KUZUYA, H
    IMURA, H
    BELL, GI
    STEINER, DF
    [J]. SCIENCE, 1988, 240 (4853) : 784 - 787