A MUTATION IN THE INSULIN-RECEPTOR GENE THAT IMPAIRS TRANSPORT OF THE RECEPTOR TO THE PLASMA-MEMBRANE AND CAUSES INSULIN-RESISTANT DIABETES

被引：145

作者：

ACCILI, D

FRAPIER, C

MOSTHAF, L

MCKEON, C

ELBEIN, SC

PERMUTT, MA

RAMOS, E

LANDER, E

ULLRICH, A

TAYLOR, SI

机构：

[1] GENENTECH INC,S SAN FRANCISCO,CA 94080

[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110

[3] UNIV MARYLAND,DEPT INTERNAL MED,BALTIMORE,MD 21201

[4] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[5] HARVARD UNIV,CAMBRIDGE,MA 02138

来源：

EMBO JOURNAL | 1989年 / 8卷 / 09期

关键词：

D O I：

10.1002/j.1460-2075.1989.tb08388.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2509 / 2517

页数：9

共 53 条

[31] AN HSP70-LIKE PROTEIN IN THE ER - IDENTITY WITH THE 78 KD GLUCOSE-REGULATED PROTEIN AND IMMUNOGLOBULIN HEAVY-CHAIN BINDING-PROTEIN
MUNRO, S
PELHAM, HRB
[J]. CELL, 1986, 46 (02) : 291 - 300
[32] DETECTION OF SINGLE BASE SUBSTITUTIONS BY RIBONUCLEASE CLEAVAGE AT MISMATCHES IN RNA-DNA DUPLEXES
MYERS, RM
LARIN, Z
MANIATIS, T
[J]. SCIENCE, 1985, 230 (4731) : 1242 - 1246
[33] ODAWARA M, 1989, IN PRESS SCIENCE
[34] DEFECTS IN HUMAN INSULIN-RECEPTOR GENE-EXPRESSION
OJAMAA, K
HEDO, JA
ROBERTS, CT
MONCADA, VY
GORDEN, P
ULLRICH, A
TAYLOR, SI
[J]. MOLECULAR ENDOCRINOLOGY, 1988, 2 (03) : 242 - 247
[35] INSULIN-RECEPTORS ON CHINESE-HAMSTER OVARY (CHO) CELLS - ALTERED INSULIN BINDING TO GLYCOSYLATION MUTANTS
PODSKALNY, J
MCELDUFF, A
GORDEN, P
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) : 70 - 75
[36] A CHIMERIC RECEPTOR ALLOWS INSULIN TO STIMULATE TYROSINE KINASE-ACTIVITY OF EPIDERMAL GROWTH-FACTOR RECEPTOR
RIEDEL, H
DULL, TJ
SCHLESSINGER, J
ULLRICH, A
[J]. NATURE, 1986, 324 (6092) : 68 - 70
[37] RONNETT GV, 1984, J BIOL CHEM, V259, P4566
[38] TUNICAMYCIN-MEDIATED DEPLETION OF INSULIN RECEPTORS IN 3T3-L1 ADIPOCYTES
ROSEN, OM
CHIA, GH
FUNG, C
RUBIN, CS
[J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1979, 99 (01) : 37 - 42
[39] A POINT MUTATION IN THE EXTRACELLULAR DOMAIN OF THE HUMAN CSF-1 RECEPTOR (C-FMS PROTO-ONCOGENE PRODUCT) ACTIVATES ITS TRANSFORMING POTENTIAL
ROUSSEL, MF
DOWNING, JR
RETTENMIER, CW
SHERR, CJ
[J]. CELL, 1988, 55 (06) : 979 - 988
[40] PRIMER-DIRECTED ENZYMATIC AMPLIFICATION OF DNA WITH A THERMOSTABLE DNA-POLYMERASE
SAIKI, RK
GELFAND, DH
STOFFEL, S
SCHARF, SJ
HIGUCHI, R
HORN, GT
MULLIS, KB
ERLICH, HA
[J]. SCIENCE, 1988, 239 (4839) : 487 - 491

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