4-HYDROXY-3-NITROSOBENZAMIDE AND ITS FERROUS CHELATE FROM STREPTOMYCES-MURAYAMAENSIS

被引:20
作者
CONE, MC [1 ]
MELVILLE, CR [1 ]
CARNEY, JR [1 ]
GORE, MP [1 ]
GOULD, SJ [1 ]
机构
[1] OREGON STATE UNIV,DEPT CHEM,CORVALLIS,OR 97331
关键词
D O I
10.1016/0040-4020(95)00071-F
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Two new colored metabolites of Streptomyces murayamaensis have been isolated and characterized as 4-hydroxy-3-nitrosobenzamide and its ferrous chelate. These structures have been confirmed by synthesis via a modified Baudisch reaction. A sample of 3-amino-4-hydroxy[2-H-2]benzoic acid was fed to S. murayamaensis, affording a sample of the 4-hydroxy-3-nitrosobenzamide ferrous chelate deuterated at C-2 (28.5% enrichment, 3.2% incorporation).
引用
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页码:3095 / 3102
页数:8
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