A CONJUGATE OF LACTOSAMINATED POLY-L-LYSINE WITH ADENINE-ARABINOSIDE MONOPHOSPHATE, ADMINISTERED TO MICE BY INTRAMUSCULAR ROUTE, ACCOMPLISHES A SELECTIVE DELIVERY OF THE DRUG TO THE LIVER

被引：22

作者：

FIUME, L

DISTEFANO, G

BUSI, C

MATTIOLI, A

机构：

[1] Dipartimento di Patologia Sperimentale, Universitá di Bologna, I-40126 Bologna

来源：

BIOCHEMICAL PHARMACOLOGY | 1994年 / 47卷 / 04期

关键词：

D O I：

10.1016/0006-2952(94)90126-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A conjugate of the antiviral agent adenine arabinoside monophosphate (ara-AMP) with a low molecular mass lactosaminated poly-L-lysine, administered to mice by i.m. route, selectively delivers the drug to the liver. In mice the conjugate is devoid of acute toxicity even at high dose (1.3 mg/g) and injected i.m. for 20 days does not induce antibodies. Moreover it is highly soluble in water; this means that a pharmacologically active dose may be administered in a small volume compatible with the i.m. route. Compared to the similar ara-AMP complex with lactosaminated albumin which must be injected intravenously, the present conjugate might assure a better compliance of patients with hepatitis B virus infection for a long lasting, liver targeted antiviral treatment.

引用

页码：643 / 650

页数：8

共 30 条

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