PERIPHERAL METABOLISM OF PARATHYROID-HORMONE

被引：244

作者：

MARTIN, KJ ^{[1
]}

HRUSKA, KA ^{[1
]}

FREITAG, JJ ^{[1
]}

KLAHR, S ^{[1
]}

SLATOPOLSKY, E ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV RENAL,ST LOUIS,MO 63110

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1979年 / 301卷 / 20期

关键词：

D O I：

10.1056/NEJM197911153012005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AFTER the radioimmunoassay for parathyroid hormone (PTH) was introduced by Berson et al. in 1963,1 initial enthusiasm for its clinical application was tempered because widely differing results were reported from several laboratories.2 3 4 5 The overlap of serum levels of immunoreactive PTH (iPTH) between normal subjects and patients with hyperparathyroidism ranged from 0 to 50 per cent. In addition, whereas Reiss and Canterbury3 reported that serum levels of iPTH were not reduced by calcium infusion in patients with parathyroid adenomas, Potts and his coworkers4 found marked suppression of serum iPTH levels in response to induced hypercalcemia in a similar group of patients. © 1979, Massachusetts Medical Society. All rights reserved.

引用

页码：1092 / 1098

页数：7

共 74 条

[21] METABOLISM OF PARATHYROID-HORMONE BY FETAL RAT CALVARIA [J].

FREITAG, JJ ;

MARTIN, KJ ;

CONRADES, MB ;

SLATOPOLSKY, E .

ENDOCRINOLOGY, 1979, 104 (02) :510-516

[22] EXAMINATION OF REQUIREMENT FOR METABOLISM OF PARATHYROID-HORMONE IN SKELETAL TISSUE BEFORE BIOLOGICAL ACTION [J].

GOLTZMAN, D .

ENDOCRINOLOGY, 1978, 102 (05) :1555-1562

[23] METABOLISM AND BIOLOGICAL-ACTIVITY OF PARATHYROID-HORMONE IN RENAL CORTICAL MEMBRANES [J].

GOLTZMAN, D ;

PEYTREMANN, A ;

CALLAHAN, EN ;

SEGRE, GV ;

POTTS, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (01) :8-19

[24]

GRACE S G, 1974, Surgical Forum (Chicago), V25, P323

[25]

HABENER JF, 1976, METABOLISM, V25, P385, DOI 10.1016/0026-0495(76)90070-6

[26] PARATHYROID HORMONE - SECRETION AND METABOLSIM IN-VIVO [J].

HABENER, JF ;

POWELL, D ;

MURRAY, TM ;

MAYER, GP ;

POTTS, JT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (12) :2986-&

[27] RESPONSIVENESS OF NEOPLASTIC AND HYPERPLASTIC PARATHYROID TISSUES TO CALCIUM INVITRO [J].

HABENER, JF .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (02) :436-450

[28] CALCIUM-DEPENDENT INTRACELLULAR DEGRADATION OF PARATHYROID-HORMONE - POSSIBLE MECHANISM FOR REGULATION OF HORMONE STORES [J].

HABENER, JF ;

KEMPER, B ;

POTTS, JT .

ENDOCRINOLOGY, 1975, 97 (02) :431-441

[29]

HABENER JF, 1976, HDB PHYSIOLOGY 7, V7, P313

[30]

HAMILTON JW, 1971, J BIOL CHEM, V246, P3224

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