FLUORESCENCE INSITU HYBRIDIZATION - APPLICATIONS IN CYTOGENETICS AND GENE-MAPPING

被引：366

作者：

TRASK, BJ

机构：

[1] B.J. Trask is in the Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 05期

关键词：

D O I：

10.1016/0168-9525(91)90378-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Unique sequences, chromosomal subregions, or entire genomes can be specifically highlighted in metaphase or interphase cells by fluorescence in situ hybridization (FISH). This technique can be used to identify chromosomes, detect chromosomal abnormalities or determine the chromosomal location of specific sequences. FISH plays an increasingly important role in a variety of research areas, including cytogenetics, prenatal diagnosis, tumor biology, gene amplification and gene mapping.

引用

页码：149 / 154

页数：6