THE DISTRIBUTION OF OMEGA-CONOTOXIN MVIIC(NLE)-BINDING SITES IN RAT-BRAIN MEASURED BY AUTORADIOGRAPHY

被引：18

作者：

FILLOUX, F

KARRAS, J

IMPERIAL, JS

GRAY, WR

OLIVERA, BM

机构：

[1] UNIV UTAH,DEPT PEDIAT,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,DEPT PSYCHIAT,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,DEPT BIOL,SALT LAKE CITY,UT 84132

来源：

NEUROSCIENCE LETTERS | 1994年 / 178卷 / 02期

关键词：

OMEGA-CONOTOXIN; OMEGA-CONOTOXIN MVIIC; CALCIUM CHANNEL; NEURONAL CHANNEL; SYNAPSE; NEUROTRANSMITTER RELEASE; CEREBELLUM;

D O I：

10.1016/0304-3940(94)90774-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An analogue of omega-conotoxin MVIIC, [I-125]omega-MVIIC(n/e) has been employed in an autoradiographic assay to define the distribution of binding sites in rat brain of this neuronal calcium channel antagonist. In comparison with N-type channels (labeled by [I-125]omega-conotoxin GVIA), omega-MVIIC(n/e) sites are much denser in cerebellum (molecular layer) than in forebrain. Binding in thalamus is also comparatively high for omega-MVIIC(n/e). Under these conditions, [(125I)]omega-MVIIC(n/e) binding to rat brain sections is not displaceable by the N-channel antagonist, omega-conotoxin GVIA. The calcium channel blocker I-125]omega-conotoxin MVIIC(n/e) labels a unique set of binding sites in mammalian brain.

引用

页码：263 / 266

页数：4

共 13 条

[1] TOXITYPING RAT-BRAIN CALCIUM CHANNELS WITH OMEGA-TOXINS FROM SPIDER AND CONE SNAIL VENOMS [J].