PREPARATION, CHARACTERIZATION, AND ANTIVIRAL ACTIVITY OF MICROBIAL METABOLITES OF STEMODIN

被引：37

作者：

HUFFORD, CD

BADRIA, FA

ABOUKARAM, M

SHIER, WT

ROGERS, RD

机构：

[1] UNIV MISSISSIPPI,SCH PHARM,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

[2] UNIV MINNESOTA,COLL PHARM,DEPT MED CHEM,MINNEAPOLIS,MN 55455

[3] NO ILLINOIS UNIV,DEPT CHEM,DE KALB,IL 60155

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 06期

关键词：

D O I：

10.1021/np50078a008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Screening studies for microbial transformation products of stemodin [2] have identified a number of microbial metabolites. Scale-up fermentation with Rhizopus arrhizus ATCC 11145 and Streptomyces sp. NRRL 5691 have resulted in the production of five metabolites that have been characterized with the use of 2D nmr and X-ray techniques. These metabolites have been identified as 18-hydroxystemodin [6], 16,18-dihydroxystemodin [7], 8-beta-hydroxystemodin [8], 8-beta,18-dihydroxystemodin [9], and 7-beta,8-beta-dihydroxystemodin [10]. The antiviral activity and cytotoxicity of the isolated metabolites have been evaluated.

引用

页码：1543 / 1552

页数：10

共 13 条

[1] A SIMPLIFIED PLAQUE REDUCTION ASSAY FOR ANTIVIRAL AGENTS FROM PLANTS - DEMONSTRATION OF FREQUENT OCCURRENCE OF ANTIVIRAL ACTIVITY IN HIGHER-PLANTS [J].