APPLICATION OF HYGROMYCIN A STRUCTURE-ACTIVITY-RELATIONSHIPS TO THE ANTIBIOTIC A201A

被引:5
作者
HECKER, SJ
LILLEY, SC
MINICH, ML
WERNER, KM
机构
[1] Pfizer Inc, Central Research Division, Groton
关键词
D O I
10.1016/S0960-894X(01)80896-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Replacement of the disaccharide portion of A201A with an allyl ether, with concomitant 3-hydroxylation, affords an analog with biological activity comparable to that of the natural product. The response of biological activity to this modification closely parallels that observed with hygromycin A, which implies that these two natural products may share a common binding site.
引用
收藏
页码:295 / 298
页数:4
相关论文
共 15 条
[1]  
CHIDA N, 1991, J ORG CHEM
[2]  
EPP K, 1976, 16TH INT C ANT AG CH
[3]  
Gale EF, 1981, MOL BASIS ANTIBIOTIC
[4]   SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .3. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF AMINOCYCLITOL ANALOGS [J].
HECKER, SJ ;
LILLEY, SC ;
MINICH, ML ;
WERNER, KM .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (09) :1015-1018
[5]   HYGROMYCIN-A - PREPARATION OF AMINOCYCLITOL ANALOGS DEFINING THE MINIMUM FUNCTIONALITY REQUIRED FOR BIOLOGICAL-ACTIVITY [J].
HECKER, SJ ;
LILLEY, SC ;
WERNER, KM .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (09) :1043-1046
[6]   SEMISYNTHETIC MODIFICATION OF HYGROMYCIN-A .1. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF VINYL METHYL AND AMIDE ANALOGS [J].
HECKER, SJ ;
MINICH, ML ;
WERNER, KM .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (06) :533-536
[7]  
HECKER SJ, UNPUB
[8]  
JAYNES BH, IN PRESS J ANTIBIOTI
[9]   THE STRUCTURE OF A201A, A NOVEL NUCLEOSIDE ANTIBIOTIC [J].
KIRST, HA ;
DORMAN, DE ;
OCCOLOWITZ, JL ;
JONES, ND ;
PASCHAL, JW ;
HAMILL, RL ;
SZYMANSKI, EF .
JOURNAL OF ANTIBIOTICS, 1985, 38 (05) :575-586
[10]  
KIRST HA, 1976, 16TH INT C ANT AG CH