PHARMACOLOGY OF SPINAL PEPTIDES AFFECTING SENSORY AND MOTOR FUNCTIONS - DYNORPHINS, SOMATOSTATINS AND TACHYKININS

In recent years, the pharmacological activity of dynorphins and somatostatins on spinal sensory transmission has been intensively investigated with a view to developing new agents for pain control. Similarly, a series of tachykinin-related peptides with apparent receptor antagonist activity on endogenous substance P and neurokinins has been investigated. However, a number of observations suggest that these peptides, injected intrathecally in laboratory animals, not only exert a direct effect on nociceptive transmission but also affect a broader range of spinal somatomotor and autonomic functions and may cause peculiar neurotoxic effects that are not elicited by a large number of peptides affecting spinal neurotransmission. This article makes a critical review of their pharmacological activity on spinal sensory and motor functions and briefly touches on their anatomical and functional organization in the spinal cord. © 1991 The Italian Pharmacological Society.